Paper-based platforms for biological sensing
The recent advent of paper-based microfluidics provides a rapid, rugged and low-cost alternative to traditional microfluidics. Three-dimensional microfluidic paper analytical devices (µPADs) are a new type of analytical device, ideally suited to resource-limited environments and field applications, both diagnostic and environmental.
µPADs are easy to fabricate in complex geometries, and largely rely on capillary wicking rather than active pumping to move fluids. The necessary reagents for chemical and biological analyses can be stored inside the device in a dry form to minimize manual operations by the user—paper is very biocompatible, and allows stable storage of reagents. To run a complete assay, the user simply adds the sample and a buffer solution—or water, if buffer salts are stored on-chip—to the device.
In this talk, we will review the current state-of-the-art, and discuss applications of µPADs in the field, at the point of care and at the point of use.